Birds as Potential Models in Ischemic Injury (Peter Proctor, 23 July 2010)
Humans differ from traditional animal models for acute ischemic injury (as in stroke ) in that they have high blood levels of the conditionally pro- or anti-oxidant and antiexcitotoxic agent uric acid. Urate has even been proposed as a treatment for stroke. High human levels of blood urate may partially-explain the repeated failure of human stroke trials with "urate-like" antioxidant or antiexcitotoxic drugs which had worked well in animal models.
Birds also use uric acid as an important antioxidant, e.g, in read full comment
Comment on: Sicard et al. Experimental & Translational Stroke Medicine, 1:7
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Birds as Potential Models in Ischemic Injury (Peter Proctor, 23 July 2010)
Humans differ from traditional animal models for acute ischemic injury (as in stroke ) in that they have high blood levels of the conditionally pro- or anti-oxidant and antiexcitotoxic agent uric acid. Urate has even been proposed as a treatment for stroke. High human levels of blood urate may partially-explain the repeated failure of human stroke trials with "urate-like" antioxidant or antiexcitotoxic drugs which had worked well in animal models.
read full comment
Birds also use uric acid as an important antioxidant, e.g, in
Comment on: Sicard et al. Experimental & Translational Stroke Medicine, 1:7