Review
An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice
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* Corresponding author: Christiane Albert-Weißenberger Albert_C2@klinik.uni-wuerzburg.de
1 University of Würzburg, Department of Neurology, Würzburg, Germany
2 University of Würzburg, Department of Neuroradiology Würzburg, Germany
3 University of Würzburg, Department of Neurosurgery, Würzburg, Germany
Experimental & Translational Stroke Medicine 2012, 4:1 doi:10.1186/2040-7378-4-1
Published: 2 February 2012Abstract
Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.