Table 1

Comparison of CCSVI studies

method of detection

no. of patients

no. of control subjects

main findings

CCSVI in MS

author

year

ref


TCCS

89 MS

60

alterations of intracranial venous haemodynamics in MS patients

+

Zamboni et al.

2007

[5]

TCCS-ECD

(+ selective venography)

65 MS

(65 MS)

235

(48)

high association of venous outflow anomalies with MS (OR43). Selective venography: multiple extracranial venous stenoses in all MS but none of the control subjects

+

Zamboni et al.

2009

[6]

TCCS-ECD

109 MS

177

presence of CCSVI (≥ 2 criteria) in all MS patients but none of the controls

+

Zamboni et al.

2009

[1]

ECD

70 MS

n/a

extracranial signs of abnormal venous outflow in 91,4% of MS patients

+

Simka et al.

2010

[10]

ECD

25 MS

25

extracranial signs of CCSVI (≥ 2 criteria) in 84% of MS patients but none of the controls

+

Al-Omari and Rousan

2010

[11]

TCCS-ECD

56 MS

20

absence of CCSVI (≥ 2 criteria) in all MS and control subjects

-

Doepp et al.

2010

[13]

TCCS-ECD

20 MS

20

absence of CCSVI (≥ 2 criteria) in all MS and 95% of controls

-

Mayer et al.

2011

[14]

TCCS-ECD

289 MS

21 CIS

189

Higher prevalence of CCSVI (≥ 2 criteria) in MS (56,1%) compared to healthy controls but low sensitivity/specificity

+/-

Zivadinov et al.

2011

[15]

TCCS-ECD

(selective venography)

50 CIS

(7 CIS)

170

Ultrasound criteria for CCSVI in 8 CIS patients, no venous anomalies detected by venography.

-

Baracchini et al.

2011

[12]

selective venography

31 MS

11 CIS

n/a

extracranial venous outflow anomalities infrequent in early MS, more prevalent in late MS

+/-

Yamout et al.

2010

[22]

selective venography

342 MS

n/a

venous stenoses detected in 97% of patients previously diagnosed with CCSVI by ultrasound

+

Ludyga et al.

2010

[23]


Recent studies addressing the presence of chronic cerebrospinal venous insufficiency (CCSVI) by high resolution echocolor Doppler (ECD), transcranial color Doppler sonography (TCCS) and/or selective venography.

Waschbisch et al. Experimental & Translational Stroke Medicine 2011 3:7   doi:10.1186/2040-7378-3-7

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