Research
Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke
1 Department of Neurology, Georgia Health Sciences University, Augusta, GA, USA
2 Department of Physiology, Georgia Health Sciences University, Augusta, GA, USA
3 Department of Medicine, Georgia Health Sciences University, Augusta, GA, USA
4 Department of Biostatistics, Georgia Health Sciences University, Augusta, GA, USA
5 Department of Cell Biology and Anatomy, Georgia Health Sciences University, Augusta, GA, USA
6 Charlie Norwood VA Medical Center, Augusta, GA, USA
Experimental & Translational Stroke Medicine 2011, 3:16 doi:10.1186/2040-7378-3-16
Published: 16 December 2011Additional files
Additional file 1:
Additional Figure 1, (Figure S1). Representative PeriScan scanning imaging of brain at 1 hour after stroke (PeriScan PIM 3 System, North Royalton, Ohio).
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Additional file 2:
Additional Figure 2 (Figure S2). Representative PeriScan scanning imaging of brain at 24 hours after stroke (PeriScan PIM 3 System, North Royalton, Ohio).
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Additional file 3:
Additional Figure 3 (Figure S3). Representative images of infarct volume determined by T2 diffusion-weighted MRI.
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Additional file 4:
Additional Figure 4 (Figure S4). Comparison of estrogen level in females mice (data are presented in the Results).
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Additional file 5:
Additional Figure 5 (Figure S5). Representative brain images of OVX females treated with vehicle and minocycline.
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Additional file 6:
Additional Figure 6 (Figure S6). Densitometric analysis (A) and representative Western Blots (B) of time-dependent MMP-9 expression in brain.
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Additional file 7:
Additional Figure 7 (Figure S7). Representative zymography of MMP-9 activity.
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Additional file 8:
Additional Figure 8 (Figure S8). Summarized analysis of minocycline to reduce infarct (A) and improve neurological outcomes (B) after acute ischemia.
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Additional file 9:
Additional Figure Legends. Legends for Additional Figures.
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Additional file 10:
Additional Methods. Measurement of cerebral perfusion and MRI procedure.
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