Table 1 |
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Main futures of cerebral ischemic tolerance |
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| General |
Preconditioning specific |
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| • Robust cerebroprotection |
• Two phased: early and delayed |
| • The interval between preconditioning and ischemia determines the fate |
• Early tolerance starts in minutes, delayed tolerance not usually before 24 h |
| • Ischemic tolerance is transient |
• After early phase, but before delayed phase no tolerance is achieved |
| • Ischemic tolerance can be induced by a variety of stimuli |
• Early phase is short-lasting, delayed phase longer, up to 1 week |
| • Transient ischemic attacks confer ischemic tolerance in humans |
• Preconditioning preserves cortical/penumbral tissue in focal ischemia models |
Durukan and Tatlisumak Experimental & Translational Stroke Medicine 2010 2:2 doi:10.1186/2040-7378-2-2 |
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