Table 2 |
||||
|
Effect of ONO-AE1-259-01 on Physiologic Parameters |
||||
|
Parameter |
Vehicle |
0.5 nmol |
1 nmol |
2 nmol |
|
|
||||
|
Pre-ischemia |
||||
|
pH |
7.31 ± 0.02 |
7.28 ± 0.47 |
7.30 ± 0.46 |
7.25 ± 0.23 |
|
PaCO2 |
43.2 ± 1.8 |
44.4 ± 2.0 |
45.2 ± 1.6 |
43.0 ± 1.3 |
|
PaO2 |
133 ± 5 |
139 ± 5 |
130 ± 8 |
134 ± 9 |
|
MABP |
78.6 ± 3.9 |
75.6 ± 1.7 |
77.4 ± 2.8 |
72.8 ± 2.5 |
|
Ischemia |
||||
|
pH |
7.28 ± 0.02 |
7.29 ± 0.64 |
7.26 ± 0.03 |
7.33 ± 0.02 |
|
PaCO2 |
44.0 ± 1.8 |
43.2 ± 1.5 |
45.6 ± 2.6 |
43.16 ± 1.6 |
|
PaO2 |
129 ± 5 |
133 ± 4 |
124 ± 6 |
133 ± 5 |
|
MABP |
74.4 ± 1.7 |
76.6 ± 2.5 |
74.4 ± 1.8 |
74.8 ± 1.7 |
|
Reperfusion |
||||
|
pH |
7.26 ± 0.03 |
7.28 ± 0.05 |
7.29 ± 0.40 |
7.28 ± 0.25 |
|
PaCO2 |
43.0 ± 1.8 |
45.8 ± 1.4 |
47.2 ± 1.3 |
44.8 ± 2.7 |
|
PaO2 |
135 ± 9 |
129 ± 6 |
126 ± 7 |
138 ± 9 |
|
MABP |
74.6 ± 1.3 |
73.8 ± 1.7 |
76.0 ± 1.6 |
74.0 ± 1.6 |
|
|
||||
|
Measurements were made in arterial blood samples obtained via femoral catheter (n = 5/group). |
||||
|
Ahmad et al. Experimental & Translational Stroke Medicine 2010 2:12 doi:10.1186/2040-7378-2-12 |
||||
