Figure 4.

Effect of pretreatment with ONO-AE1-259-01 on neurologic deficit scores and infarct volume after 4 days of reperfusion. Mice were pretreated with ONO-AE1-259-01 before being subjected to 90-min MCAO and 4 days of reperfusion. (A) Images of representative TTC-stained brain sections. (B) Percent corrected cortical, striatal, and hemispheric infarct volumes. (C) Neurologic deficit scores were significantly lower in mice treated with 1.0 and 2.0 nmol ONO-AE1-259-01 than in vehicle-treated mice. n = 9/group; *P < 0.05 compared with the vehicle-treated group.