Table 1

Table 1
Overview of experimental stroke models
*Cerebral Ischemia*	*Etiology*	*Reperfusion (transient ischemia) or permanent ischemia*	*Examples*



Global (complete or incomplete) = model of circulatory arrest or severe hypotension	Intravascular	Transient or permanent	Cardiac arrest with or without cardiopulmonary resuscitation

	Extravascular	Transient or permanent	Cervical compression by neck cuff; ligation of several brain-supplying arteries

Focal	Intravascular	Transient or permanent	Intraluminal thread middle cerebral artery occlusion model

	Extravascular	Transient or permanent	Surgical middle cerebral artery occlusion models using ligation, clipping, electrocauterization etc.; endothelin-1-induced middle cerebral artery occlusion

Multifocal	Intravascular	Transient (spontaneous lysis or thrombolytic therapy possible in blood clots) or permanent	Embolization models using blood clots, microspheres or other embolus material

Braeuninger and Kleinschnitz Experimental & Translational Stroke Medicine 2009 1:8 doi:10.1186/2040-7378-1-8