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Open Access Highly Accessed Review

Animal models of focal brain ischemia

Kenneth M Sicard and Marc Fisher*

Author Affiliations

Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA

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Experimental & Translational Stroke Medicine 2009, 1:7  doi:10.1186/2040-7378-1-7

Published: 13 November 2009

Abstract

Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much additional research. Animal stroke models provide an important mechanism for these activities. A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome.